Latest Research

High-throughput droplet microfluidic platform helps researchers to generate pharmaceutically relevant compound libraries

Abstract "The implementation of continuous flow technology is critical towards enhancing the application of photochemical reactions for industrial process development. However, there are significant time and resource constraints associated with translating discovery scale vial-based batch reactions to continuous flow scale-up conditions. Herein we report the development...

Multiplex nucleic acid detection

Microfluidics for CRISPR-based multiplexed detection of nucleic acids

Abstract "Fast, inexpensive, and multiplexed detection of multiple nucleic acids is of great importance to human health, yet it still represents a significant challenge. Herein, we propose a nucleic acid testing platform, named MiCaR, which couples a microfluidic device with CRISPR-Cas12a and multiplex recombinase polymerase amplification....

Microfluidic quantification of heterogeneity of bacterial populations

Microfluidic quantification of heterogeneity of bacterial populations

Abstract "Severe non-healing infections are often caused by multiple pathogens or by genetic variants of the same pathogen exhibiting different levels of antibiotic resistance. For example, polymicrobial diabetic foot infections double the risk of amputation compared to monomicrobial infections. Although these infections lead to increased morbidity...